By BLAKE BEDDINGFIELD, special correspondent

NASHVILLE, Tenn. -- This will be the first big test for the Titans this season.

The Titans will most likely be without a good portion of their roster due to Covid-19 protocols.

The number of players who will be missing for the game is undetermined but could significantly alter their game plan and how they attack the undefeated Buffalo Bills.BillsFans

The loss of defensive tackle Jeffrey Simmons significantly hinders a run defense that is still trying to find answers after allowing Vikings RB Dalvin Cook to rush for a career-high of 181 yards in Week 3.

The difference this week will be a Bills team that has put more focus on the passing game and uses the run as a supplement to their air attack.

What will the Bills do offensively to take advantage of the depleted Titans roster?

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Paul Kuharsky has covered the Tennessee Titans since 1996, first for The Tennessean, then ESPN.com and now independently at paulkuharsky.com. He is a member of the Pro Football Hall of Fame selection committee and one of the longest-tenured Titans beat reporters in the franchise's history.

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